Reaktion #1132014

Reaktionsgleichung

acetonitrile

4-aminothiophenol

triethylamine

1-iodoheptafluoro-n-propane

→

title compound

Ausbeute 63.2%

4-(heptafluoro-n-propylthio)aniline

Ausbeute 63.2%

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with an aqueous solution of 1N sodium hydroxide
2. 2
   Sonstigepurified by silica gel column chromatography (eluent:hexane:ethyl acetate=4:1)

Vorschrift

To 20 ml of an acetonitrile solution of 1.25 g of 4-aminothiophenol and 1.11 g of triethylamine, 5.91 g of 1-iodoheptafluoro-n-propane was added, and the mixture was stirred at room temperature for 3 hours. The mixture was diluted with ether, washed with an aqueous solution of 1N sodium hydroxide and purified by silica gel column chromatography (eluent:hexane:ethyl acetate=4:1) to give 1.85 g (yield 63%) of the title compound.

Quelle