Reaktion #1131004

Reaktionsgleichung

N-benzyl piperidone

pyrrolidine

water

→

1-Benzyl-4-pyrrolidin-1-yl-1,2,3,6-tetrahydropyridine

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   TemperaturThe reaction mixture was then cooled
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   workup.DISSOLUTIONThe resulting oil was dissolved in ether
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Einengenconcentrated under reduced pressure

Vorschrift

A solution containing N-benzyl piperidone 1 (5 g, 26.4 mmol) and pyrrolidine 2 (2.82 g, 39.6 mmol) in toluene (60 mL) was heated to reflux with azeotropic removal of water. The reaction mixture was then cooled and concentrated under reduced pressure. The resulting oil was dissolved in ether, dried over magnesium sulfate, and concentrated under reduced pressure. The crude enamine 3 was used in the next step.

Quelle