Reaktion #11297

Reaktionsgleichung

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

Lösungsmittel

water

acetone

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction was refluxed under nitrogen
2. 2
   TemperaturAfter 5–6 hours of reflux
3. 3
   Sonstigethe organic layer was separated
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated to dryness
6. 6
   Sonstigeto afford a white fluffy powder

Vorschrift

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5–6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

Quelle