Reaktion #1129248

Reaktionsgleichung

3-chlorobenzenesulfonyl chloride

1-ethynylcyclohexanamine

triethylamine

→

title compound

Ausbeute 94.4%

3-chloro-N-(1-ethynylcyclohexyl)benzenesulfonamide

Ausbeute 94.4%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe mixture was partitioned between ethyl acetate and 3N aq. HCl
2. 2
   WaschenThe organic layer was washed with sat. NaHCO3, brine
3. 3
   Trocknendried over Na2SO4
4. 4
   Einengenconcentrated in vacuuo

Vorschrift

To a solution of 1-ethynylcyclohexanamine (40 mg, 0.32 mmol) in CH2Cl2, was added triethylamine (68 mL, 0.48 mmol), followed by 3-chlorobenzenesulfonyl chloride (68.2 mg, 0.32 mmol). After 30 min, the mixture was partitioned between ethyl acetate and 3N aq. HCl. The organic layer was washed with sat. NaHCO3, brine, dried over Na2SO4, concentrated in vacuuo to give the title compound as a white solid (90 mg, 93% yield).

Quelle