Reaktion #1129222

Reaktionsgleichung

4-iodobenzoyl chloride

tris(2-aminoethyl)-amine

2-morpholinoethanol

diisopropylamine

→

2-morpholinoethyl 4-iodobenzoate

Ausbeute 73.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGshaken at room temperature for 2 hours
2. 2
   FiltrationThe reaction was filtered
3. 3
   Waschenthe resin was washed with dichloromethane (3×10 mL), tetrahydrofuran (2×10 mL), and diethyl ether (2×10 mL)
4. 4
   EinengenThe combined filtrates were concentrated in vacuo

Vorschrift

A 8 mL vial was charged with 2-morpholinoethanol (200 μL, 1.63 mmol), dichloromethane (5 mL), polystyrene-linked diisopropylamine (4.90 mmol), and 4-iodobenzoyl chloride (479 mg, 1.80 mmol), and the reaction mixture was shaken at room temperature. After 16 hours, the reaction mixture was charged with polystyrene-linked tris(2-aminoethyl)-amine (1.63 mmol), and shaken at room temperature for 2 hours. The reaction was filtered, and the resin was washed with dichloromethane (3×10 mL), tetrahydrofuran (2×10 mL), and diethyl ether (2×10 mL). The combined filtrates were concentrated in vacuo to give 2-morpholinoethyl 4-iodobenzoate (434 mg, 1.19 mmol) as a white solid.

Quelle