Reaktion #1126791

Reaktionsgleichung

4-[4-(Trifluoromethoxy)phenoxy]piperidine

benzyl 4-bromophenyl ether

sodium tert-butoxide

toluene

→

pale yellow crystal

Ausbeute 98.4%

1-(4-Benzyloxyphenyl)-4-[4-(Trifluoromethoxy)phenoxy]piperidine

Ausbeute 98.4%

Lösungsmittel

ethyl acetate

ethyl acetate

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux for 6 hr under Ar
3. 3
   WaschenThe organic layer was washed three times with water (100 mL×3)
4. 4
   FiltrationThe organic layer was filtered
5. 5
   Sonstigeto remove harz
6. 6
   Sonstigecondensed under reduced pressure

Vorschrift

4-[4-(Trifluoromethoxy)phenoxy]piperidine (2.61 g), benzyl 4-bromophenyl ether (2.63 g), palladium (II) acetate (0.67 mg), Tri-tert-butyl phosphonium tetraphenyl borate (1.57 mg), sodium tert-butoxide (1.06 g) and toluene (13 mL) were placed in a vessel and heated to reflux for 6 hr under Ar. The reaction mixture was then cooled to room temperature and water (100 mL) and ethyl acetate (100 mL) were added. The organic material was taken up in ethyl acetate. The organic layer was washed three times with water (100 mL×3). The organic layer was filtered to remove harz and then the organic layer was condensed under reduced pressure to afford 4.36 g (98.4% yield) of a pale yellow crystal target compound.

Quelle