Reaktion #1125303

Reaktionsgleichung

2-pyrazol-1-yl-pyrimidine

bromine

→

pure product

Ausbeute 85.0%

2-(4-Bromo-pyrazol-1-yl)-pyrimidine

Ausbeute 85.0%

Lösungsmittel

acetic acid

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter addition
2. 2
   SonstigeAfter removed the acetic acid
3. 3
   Sonstigethe crude product was purified

Vorschrift

To a solution of 2-pyrazol-1-yl-pyrimidine (0.55 g, 3.7 mmol) in acetic acid (5 mL) was added bromine (1.2 g, 7.5 mmol) in acetic acid (3 mL) dropwisely. After addition, the reaction mixture was stirred at room temperature overnight. After removed the acetic acid, the crude product was purified using column chromatography (2% methanol in dichloromethane) to give 0.7 g of pure product in 85% yield. MS (ESMS, M+H 225).

Quelle