Reaktion #1122961

Reaktionsgleichung

pyrazole

sodium hydroxide

3,6-dichloro-1,2,4-triazolo[4,3-b]pyridazine

water

→

1,2,4-triazolo[4,3-b]pyridazine

Lösungsmittel

1,2-dimethoxyethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigebrought back to a temperature in the region of 20° C.
2. 2
   SonstigeThe mixture obtained
3. 3
   Extraktionis extracted with 3×100 cm3 of dichloromethane
4. 4
   Waschenthe combined organic phases are washed with 2×100 cm3 of a saturated aqueous solution of sodium chloride
5. 5
   TrocknenThe resulting organic phase is dried over sodium sulphate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated by evaporation under reduced pressure
8. 8
   SonstigeThe yellow powder thus obtained
9. 9
   Sonstigeis purified by chromatography on silica gel (eluent: 98/2 CH2Cl2/MeOH)

Vorschrift

0.61 g of 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H)-pyrazole and 5.3 cm3 of a 1N aqueous solution of sodium hydroxide are added to a mixture of 0.5 g of commercial 3,6-dichloro-1,2,4-triazolo[4,3-b]pyridazine in 15 cm3 of 1,2-dimethoxyethane. The reaction mixture is stirred at a temperature in the region of 20° C. for 30 minutes before the addition of 92 mg of palladium dichlorobis(triphenylphosphine). The reaction mixture is then stirred at 65° C. for 30 minutes, and then brought back to a temperature in the region of 20° C. and poured into 20 cm3 of water. The mixture obtained is extracted with 3×100 cm3 of dichloromethane and the combined organic phases are washed with 2×100 cm3 of a saturated aqueous solution of sodium chloride. The resulting organic phase is dried over sodium sulphate, filtered and concentrated by evaporation under reduced pressure. The yellow powder thus obtained is purified by chromatography on silica gel (eluent: 98/2 CH2Cl2/MeOH). 0.2 g of 3-chloro-6-(1-methyl-1H)-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazine is thus obtained in the form of a beige powder, the characteristics of which are as follows:

Quelle