Reaktion #11220

ord-44e17ed999e24f12a40be8ec409048b0

Reaktionsgleichung

COc1ccc2cc(C=O)[nH]c2c1
6-methoxyindole-2-carboxaldehyde
[Br-].c1ccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
benzyltriphenylphosphonium bromide
COc1ccc2cc(C=Cc3ccccc3)[nH]c2c1
( 146 )
Ausbeute 94.0%
COc1ccc2cc(C=Cc3ccccc3)[nH]c2c1
6-Methoxy-2-[2-phenylethenyl]-1H-indole
Ausbeute 94.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Reaction of 6-methoxyindole-2-carboxaldehyde (145) with benzyltriphenylphosphonium bromide using the procedure described in example 37 gave (146) (94%) as a white solid (mixture of E/Z isomers) which was used without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094798B1uspto-grants-2006_08