Reaktion #1121753

ord-b7eda5d63df049cc95cd00179f98041d

Reaktionsgleichung

[Cl-].[K+]
KCl
CCOC(=O)C[C@H](CC(C)C)C[N+](=O)[O-]
(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester
[K+].[OH-]
KOH
Cl
HCl
→
CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].[K+]
title compound
CC(C)C[C@@H](CC(=O)[O-])C[N+](=O)[O-].[K+]
(S)-5-Methyl-3-nitromethyl-hexanoic acid monopotassium salt

Edukte

[Cl-].[K+]
KCl
CCOC(=O)C[C@H](CC(C)C)C[N+](=O)[O-]
(S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester
[K+].[OH-]
KOH
Cl
HCl

Reagenzien

Keine

Lösungsmittel

O
H2O

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe solvent was removed under reduced pressure
  2. 2
    Sonstigeto give a solid

Vorschrift

830 mg of (S)-5-methyl-3-nitromethyl-hexanoic acid ethyl ester (VIII, R1=ethyl) were suspended in 0.8 mL of H2O. 900 mg of 50% aqueous KOH were added. After 5 h at 25° C. conversion was complete (determination by HPLC). 4.2 mL of 1M aqueous HCl were added and the solvent was removed under reduced pressure to give a solid consisting of the title compound and KCl.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08546112B2uspto-grants-2013_10