Reaktion #1121550

Reaktionsgleichung

Trifluoroacetic acid

1-(2-bromophenyl)-2-phenylethan-1-ol

triethylsilane

→

1-(2-bromophenyl)-2-phenylethane

Ausbeute 52.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe excess trifluoroacetic acid was removed under reduced pressure
2. 2
   workup.DISSOLUTIONThe residue was dissolved in ether
3. 3
   Waschenwashed successively with water, aqueous sodium bicarbonate (×3) and water (×2)
4. 4
   Sonstigedried
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   Sonstigechromatographed

Vorschrift

Trifluoroacetic acid (46 ml) was added in one portion to a stirred mixture of 1-(2-bromophenyl)-2-phenylethan-1-ol (16.51 g, prepared as described in Example 3) and triethylsilane (13.80 g). The resulting mixture was stirred at room temperature for about 22 hours, then the excess trifluoroacetic acid was removed under reduced pressure. The residue was dissolved in ether and washed successively with water, aqueous sodium bicarbonate (×3) and water (×2), then dried, concentrated under reduced pressure, and chromatographed using 10% dichloromethane in petrol as eluant to give 1-(2-bromophenyl)-2-phenylethane (8.02 g, 52%) as a colourless oil.

Quelle