Reaktion #11211

Reaktionsgleichung

acid ( 117 )

3-(4-(2-Chlorophenyl)-9-hydroxy-1,3-dioxo-2,3-dihydropyrrolo[3,4-c]carbazol-6 (1H)-yl)propanoic acid

oxalyl chloride

cis-2,6-dimethylpiperazine

→

amide

Ausbeute 76.0%

4-(2-Chlorophenyl)-6-{3-[cis-3,5-dimethylpiperazinyl]-3-oxopropyl}-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Ausbeute 76.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeprepared

Vorschrift

Reaction of acid (117) prepared as described in example 230 with oxalyl chloride followed by cis-2,6-dimethylpiperazine using the procedure described in example 207 gave the amide (126) (76%) as a yellow powder, mp 168–173° C. (dec). 1H NMR δ [(CD3)2SO] 11.13 (br, 1H), 8.52 (d, J=2.6 Hz, 1H), 7.80 (s, 0.5H), 7.76 (s, 0.5H), 7.71 (m, 1H), 7.58 (m, 1H), 7.54–7.43 (m, 3H), 7.31 (dd, J=9.0, 2.6 Hz, 1H), 4.71 (m, 2H), 4.17 (m, 1H), 3.89 (s, 3H), 2.94 (m, 1H), 2.75 (m, 1H), 2.23 (m, 1H), 2.08 (m, 1H), 1.87 (m, 2H), 0.88, 0.86 (2d, J=5.9 Hz, 3H), 0.67 (d, J=6.1 Hz, 3H). Found: C, 64.03; H, 5.47, N, 9.72. C30H29ClN4O4.H2O requires C, 64.00; H, 5.55; N, 9.95.

Quelle