Reaktion #1120230

Reaktionsgleichung

5-acetylaminomethyl-2-chloroacetylfuran

diaminomethylenethiourea

→

4-(5-acetylaminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole

Ausbeute 46.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated in vacuo
2. 2
   workup.DISSOLUTIONthe residue was dissolved in water (300 ml)
3. 3
   FiltrationThe resulting precipitate was collected by filtration
4. 4
   Waschenwashed with water
5. 5
   Sonstigerecrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether

Vorschrift

A solution of 5-acetylaminomethyl-2-chloroacetylfuran (39.9 g) and diaminomethylenethiourea (21.9 g) in ethanol (400 ml) was refluxed for two hours with stirring. The solvent was evaporated in vacuo and the residue was dissolved in water (300 ml). The solution was basified with an aqueous potassium carbonate. The resulting precipitate was collected by filtration, washed with water and recrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether to afford 4-(5-acetylaminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (24.1 g).

Quelle