Reaktion #1116397

Reaktionsgleichung

83

1-Chloro-5H-benzo[c][1,8]naphthyridin-6-one

1-ethynylnaphthalene

→

253

Ausbeute 66.5%

1-(1-Naphthylethynyl)benzo[c]-1,8-naphthyridin-6(5H)-one

Ausbeute 66.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was synthesized

Vorschrift

The title compound was synthesized according to the procedure described for the preparation of Example 160 using 83 (100 mg, 0.43 mmol) and 1-ethynylnaphthalene (0.09 mL, 0.65 mmol) to provide 253 (99 mg, 66% yield) as a tan solid. LC-MS (M+H=347 obsd.=347). 1H NMR (400 MHz, d6-DMSO): δ 12.25 (s, 1H), 9.89 (d, 1H), 8.55 (d, 1H), 8.46 (d, 2H), 8.16 (d, 1H), 8.10 (m, 2H), 8.01 (m, 1H), 7.75 (m, 5H).

Quelle