Reaktion #1116

Reaktionsgleichung

sodium bicarbonate

3,4-dichloro-2-ethylpyridine

4-(2,4-dichlorobenzylidene)cyclohexylamine

ammonium chloride

→

3-Chloro-4-[4-(2,4-dichlorobenzylidene)cyclohexyl]amino-2-ethylpyridine

Ausbeute 7.0%

Lösungsmittel

N-methylpyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionextracted with ethyl acetate
3. 3
   SonstigeThe product is purified by chromatography on silica gel

Vorschrift

1.6 g of 3,4-dichloro-2-ethylpyridine and 2.5 g of 4-(2,4-dichlorobenzylidene)cyclohexylamine are heated at 180° C. for 3.5 hours together with 55 g of ammonium chloride in 9 ml of N-methylpyrrolidone. After cooling, the mixture is poured into saturated sodium bicarbonate solution and extracted with ethyl acetate. The product is purified by chromatography on silica gel using ethyl acetate/heptane 1:4. Yield: 7%

Quelle