Reaktion #1115188

Reaktionsgleichung

6-bromo-5-fluoro-1H-indole-3-carbonitrile

cesium carbonate

cyclobutylbromide

→

6-bromo-1-cyclobutyl-5-fluoro-1H-indole-3-carbonitrile

Ausbeute 91.1%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to room temperature
2. 2
   SonstigeThe precipitate was collected
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried

Vorschrift

To 6-bromo-5-fluoro-1H-indole-3-carbonitrile (49.2 g, 206 mmol) [prepared as in Example 6, Step B] was added cesium carbonate (133 g, 408 mmol), DMF (200 mL), and cyclobutylbromide (30 mL, 311 mmol). This mixture was stirred at 90° C. for three days, cooled to room temperature and poured into ice water. The precipitate was collected, washed with water and dried to give 6-bromo-1-cyclobutyl-5-fluoro-1H-indole-3-carbonitrile as a light grey solid (55 g, 90%).

Quelle