Reaktion #11135

Reaktionsgleichung

HCl

2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indole

2-bromoethyl tetrahydro-2H-pyran-2-yl ether

→

2-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol

Ausbeute 86.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Vorschrift

Alkylation of 2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indole (27) prepared according to example 37 with 2-bromoethyl tetrahydro-2H-pyran-2-yl ether using the procedure described in example 38 followed by reaction of the crude product with 2N HCl in methanol gave 2-{2-[2-(2-Chlorophenyl)ethenyl]-5-methoxy-1H-indol-1-yl}ethanol (III; Ar=2-chlorophenyl, R10═CH2CH2OH) (44) in a yield of 86% as a mixture of E/Z isomers, which was used without further purification.

Quelle