Reaktion #1109788

Reaktionsgleichung

hydrogen chloride ethanol

tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[2-oxo-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-1(2H)-yl]methyl}-1,4-oxazepane-4-carboxylate

→

title compound

Ausbeute 186.9%

1-{[(6S,7R)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]methyl}-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-2(1H)-one monohydrochloride

Ausbeute 186.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 80° C. for 15 min
2. 2
   EinengenThe reaction mixture was concentrated under reduced pressure
3. 3
   Filtrationthe residue was collected by filtration
4. 4
   Waschenwashed with ethanol-hexane

Vorschrift

A 14 N hydrogen chloride-ethanol solution (2 mL, 28.00 mmol) was added to a solution of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[2-oxo-3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)pyridin-1(2H)-yl]methyl}-1,4-oxazepane-4-carboxylate (795 mg, 1.48 mmol) in ethanol (8 mL). The reaction mixture was stirred at room temperature for 3 hr, and at 80° C. for 15 min. The reaction mixture was concentrated under reduced pressure, and the residue was collected by filtration, and washed with ethanol-hexane to give the title compound (655 mg, 1.383 mmol, 93%).

Quelle