Reaktion #1109035

Reaktionsgleichung

189c

tert-Butyl 4-(5-(Diphenylmethyleneamino)pyrazin-2-yl)piperazine-1-carboxylate

sodium acetate

hydroxylamine hydrochloride

→

189d

Ausbeute 83.1%

tert-Butyl 4-(5-Aminopyrazin-2-yl)piperazine-1-carboxylate

Ausbeute 83.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenIt was then concentrated under reduced pressure
2. 2
   Sonstigethe residue was purified by column chromatography
3. 3
   Wascheneluting with 15:1 dichloromethane/methanol

Vorschrift

To a solution of 189c (2.5 g, 5.6 mmol) in methanol (25 mL) was added sodium acetate (0.56 g, 6.8 mmol) and hydroxylamine hydrochloride (0.7 g, 10 mmol). The reaction mixture was stirred for 0.5 h. It was then concentrated under reduced pressure and the residue was purified by column chromatography eluting with 15:1 dichloromethane/methanol to afford 189d (1.3 g, 71%). MS: [M+H]+ 280.3.

Quelle