Reaktion #1108534

Reaktionsgleichung

2-Fluoro-4-(trifluoromethyl)benzaldehyde

sodium methoxide

→

2-methoxy-4-(trifluoromethyl)benzaldehyde

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was then partially concentrated
2. 2
   workup.ADDITIONdiluted with ethyl acetate and water
3. 3
   SonstigeThe layers were separated
4. 4
   Trocknenthe organic layer was dried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated

Vorschrift

2-Fluoro-4-(trifluoromethyl)benzaldehyde (5.0 g, 26 mmol) was diluted with sodium methoxide (57 ml of 0.5 M in methanol; 29 mmol), heated to 50° C. and stirred for 6 hours. The reaction was then partially concentrated, diluted with ethyl acetate and water. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield 2-methoxy-4-(trifluoromethyl)benzaldehyde (4.5 g, 22 mmol, 85% yield).

Quelle