Reaktion #1107

Reaktionsgleichung

4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine

→

4-(4-tert-Butylcyclohexylamino)-3-methoxy-2-methylpyridine

Lösungsmittel

water

methanol

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeare hydrogenated at room temperature
2. 2
   Sonstigenormal pressure until absorption of hydrogen
3. 3
   FiltrationAfter filtering
4. 4
   Einengenconcentrating 1 g of syrup

Vorschrift

1 g of 4-(4-tert-butylanilino)-3-methoxy-2-methylpyridine in 20 ml of methanol, 3.7 ml of 2N HCl and 1.3 ml of water are hydrogenated at room temperature and normal pressure until absorption of hydrogen has ended using 1 g of rhodium on alumina (5% strength). After filtering and concentrating 1 g of syrup remains=100% isomer mixture.

Quelle