Reaktion #1106678

Reaktionsgleichung

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine

sulfamide

Chloroform

→

title compound

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)sulfamide

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux overnight
3. 3
   Sonstigethe precipitate was removed by filtration
4. 4
   EinengenThe filtrate was concentrated under vacuum
5. 5
   Sonstigepurified by chromatography (2% to 8% acetone in dichloromethane)

Vorschrift

((3,4-Dihydro-2H-benzo[b][1,4]dioxepin-3-yl)methyl)amine (2.90 g, 16.2 mmol) and sulfamide (3.11 g, 32.4 mmol) were combined in dry dioxane (60 ml) and heated to reflux overnight. Chloroform was added and the precipitate was removed by filtration. The filtrate was concentrated under vacuum and purified by chromatography (2% to 8% acetone in dichloromethane) to yield the title compound as an off-white solid.

Quelle