Reaktion #1106668

Reaktionsgleichung

Compound 17

1-Chloro-5-(2-(dimethylamino)ethylamino)anthracene-9,10-dione

ethanolamine

→

Compound 21

Ausbeute 38.8%

1-(2-(dimethylamino)ethylamino)-5-(2-hydroxyl ethylamino)anthracene-9,10-dione

Ausbeute 38.8%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to room temperature
2. 2
   Extraktionextracted with water and brine
3. 3
   TrocknenThe organic layer was dried (Na2SO4)
4. 4
   Sonstigeevaporated

Vorschrift

A mixture of Compound 17 (0.87 g, 2.7 mmol) and ethanolamine (0.8 mL, 13.23 mmol) was heated in an oil bath (−150° C.) for 18 hours. The mixture was cooled to room temperature, dissolved in 100 mL CH2Cl2 and extracted with water and brine. The organic layer was dried (Na2SO4) and evaporated to provide Compound 21 (370 mg). This product was used in the next step without any purification. Rf (9:1 CHCl3/MeOH) 0.19. The structure of Compound 21 is given below:

Quelle