Reaktion #1106

Reaktionsgleichung

4-chloro-3-methoxy-2-methylpyridine

4-tert-butylaniline

NaOH

→

4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

Lösungsmittel

phenol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionthe product is extracted
3. 3
   EinengenAfter concentrating
4. 4
   workup.DISTILLATIONthe excess of amine is distilled off in vacuo
5. 5
   Sonstigethe residue is crystallized

Vorschrift

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

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