Reaktion #1105855

Reaktionsgleichung

3-bromopropanol

2-Hydroxythiophenol

DMF

Cs2CO3

→

2-(3-Hydroxy-propylsulfanyl)-phenol

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with EtOAc
2. 2
   WaschenThe combined extracts were washed with water
3. 3
   Trocknendried over magnesium sulfate
4. 4
   Einengenconcentrated to a clear oil (2.36 g, 100%)

Vorschrift

2-Hydroxythiophenol (1.00 g, 8.70 mmol) was added to a mixture of DMF (10 mL) and Cs2CO3 (2.90 g, 8.90 mmol). To this was added 3-bromopropanol (0.80 mL, 9.16 mmol) and the mixture was stirred for 20 min. The mixture was added to into water and extracted with EtOAc. The combined extracts were washed with water, dried over magnesium sulfate and concentrated to a clear oil (2.36 g, 100%). MS [M−H]− 183.

Quelle