Reaktion #1105494

Reaktionsgleichung

product

1-Benzyl-5-cycloheptylmethyl-1H-imidazole-4-carboxylic Acid

5-amino-isophthalic acid dimethyl ester

→

foam

Ausbeute 20.0%

5-[(1-Benzyl-5-cycloheptylmethyl-1H-imidazole-4-carbonyl)-amino]-isophthalic Acid Dimethyl Ester

Ausbeute 20.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product was purified by flash column chromatography (silica, DCM/ethyl acetate 92:8)

Vorschrift

The product of step b above (310 mg, 1.00 mmol) was reacted with 5-amino-isophthalic acid dimethyl ester (210 mg, 1.00 mmol) using essentially the same procedure as in Example 20, step d. The crude product was purified by flash column chromatography (silica, DCM/ethyl acetate 92:8) to afford colourless foam (110 mg, 20%). 1H NMR (300 MHz,CDCl3) 9.36 (1H, s), 8.53 (2H, s), 8.40 (1H, s), 7.35 (4H, m), 7.08 (2H, m), 5.12 (2H, s), 3.94 (6H, s), 1.90-1.22 (13H, m).

Quelle