Reaktion #1103516

Reaktionsgleichung

4-Chloro-2-phenyl quinazoline

4-aminopyridine

potassium carbonate

→

title compound

4-(4-pyridylamino)-2-phenyl quinazoline

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 4 hours
2. 2
   Einengenconcentrated under vacuum to an oil
3. 3
   workup.DISSOLUTIONThis crude material was dissolved in ethyl acetate
4. 4
   Sonstigechromatographed
5. 5
   Sonstigeto obtain solid product

Vorschrift

4-Chloro-2-phenyl quinazoline, 1 equivalent, was treated with 1 equivalent 4-aminopyridine and 1 equivalent potassium carbonate in dimethylformamide (DMF), under reflux for 4 hours. The reaction mixture was cooled to room temperature and concentrated under vacuum to an oil. This crude material was dissolved in ethyl acetate and chromatographed using hexane:ethyl acetate:methanol 8:2:0.5 to obtain solid product. Electron impact mass spectroscopy (EIMS) gave a molecular ion corresponding to the calculated molecular weight of the title compound.

Quelle