Reaktion #1102787
ord-370323f304e44fb3a147b23df98c9e9b
Reaktionsgleichung
product
2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylic acid
isopropylamine
→
title compound
2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-N-isopropyl-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxamide
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
The title compound was prepared from the product of Example 45A and commercially available isopropylamine by the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.08 (d, J=6.4 Hz, 6H), 1.44 (s, 6H), 1.47 (s, 6H), 3.89-4.00 (m, 1H), 7.66-7.80 (m, 3H), 7.91 (d, J=7.8 Hz, 1H), 11.51 (br s, 1H). MS (ESI+) m/z 473 (M+H)+. Anal. calcd. for C22H24F4N2O3S: C, 55.92; H, 5.12; N, 5.93. Found: C, 56.03; H, 5.26; N, 5.89.