Reaktion #1102783
ord-fcb08d57cc5d4ae6a93bfa0baea3d496
Reaktionsgleichung
product
2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylic acid
aminomethylcyclopropane
→
title compound
N-(cyclopropylmethyl)-2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxamide
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
The title compound was prepared from the product of Example 45A and commercially available aminomethylcyclopropane using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 0.15-0.20 (m, 2H), 0.35-0.41 (m, 2H), 0.91-1.01 (m, 1H), 1.46 (s, 6H), 1.48 (s, 6H), 3.03 (dd, J=6.1, 6.0 Hz, 2H), 7.67-7.80 (m, 3H), 8.11 (t, J=5.6 Hz, 1H), 11.56 (br s, 1H). MS (ESI+) m/z 485 (M+H)+.