Reaktion #1102779
ord-09e0e0c12f1b4579b4250c0ae5c687d9
Reaktionsgleichung
product
2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxylic acid
cyclobutylamine
→
title compound
N-cyclobutyl-2-{[2-fluoro-6-(trifluoromethyl)benzoyl]amino}-4,4,6,6-tetramethyl-4,6-dihydrothieno[2,3-c]furan-3-carboxamide
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
The title compound was prepared from the product of Example 45A and commercially available cyclobutylamine using the procedure described for Example 2B. 1H NMR (DMSO-d6, 300 MHz) δ 1.43 (s, 6H), 1.47 (s, 6H), 1.55-1.68 (m, 2H), 1.87-2.01 (m, 2H), 2.10-2.20 (m 2H), 4.21-4.35 (m, 1H), 7.66-7.80 (m, 3H), 8.28 (d, J=7.5 Hz, 1H), 11.55 (br s, 1H). MS (ESI+) m/z 485 (M+H)+. Anal. calcd. for C23H24F4N2O3S: C, 57.02; H, 4.99; N, 5.78. Found: C, 57.05; H, 5.02; N, 5.81.