Reaktion #1102759

Reaktionsgleichung

2-benzyloxy-5-bromobenzaldehyde

malonic acid

piperidine

hydrochloric acid

→

3-(2-Benzyloxy-5-bromophenyl)-acrylic acid

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperatursubsequently refluxed for 0.5 hrs
2. 2
   TemperaturAfter cooling to room temperature
3. 3
   SonstigeThe solid material that precipitated
4. 4
   Sonstigewas collected by suction
5. 5
   Sonstigerecrystallized from a minimum of boiling methanol

Vorschrift

A mixture of 2-benzyloxy-5-bromobenzaldehyde (0.10 mol), malonic acid (15.0 g), and piperidine (2.0 ml) in 150 ml of pyridine was first heated at 90° C. for 90 min and subsequently refluxed for 0.5 hrs. After cooling to room temperature, the reaction was poured on a mixture of ice (1 kg) and concentrated aqueous hydrochloric acid (250 ml). The solid material that precipitated after stirring for 2 hrs. was collected by suction and recrystallized from a minimum of boiling methanol.

Quelle