Reaktion #1100487

Reaktionsgleichung

solution

methyl 4-o-tolyl-1H-indole-2-carboxylate

N-bromosuccinimide

→

desired product

methyl 3-bromo-4-o-tolyl-1H-indole-2-carboxylate

Lösungsmittel

dichloromethane

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated
2. 2
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
3. 3
   Sonstigepurified by flash chromatography
4. 4
   Wascheneluting with 0-100% dichloromethane in hexane

Vorschrift

To a solution of EXAMPLE 126A (205 mg) in dichloromethane (5 ml) and tetrahydrofuran (5 ml) at 0° C. was added dropwise N-bromosuccinimide (144 mg) in tetrahydrofuran (3 ml). The mixture was stirred while the ice bath slowly reached room temperature. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and purified by flash chromatography, eluting with 0-100% dichloromethane in hexane to provide the desired product.

Quelle