Reaktion #1099628

Reaktionsgleichung

water

Bromine

1-(2,6-difluorophenyl)ethanone

aluminum chloride

→

title compound

Ausbeute 100.0%

2-bromo-1-(2,6-difluorophenyl)ethanone

Ausbeute 100.0%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter stirring at room temperature for 2 hr
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   WaschenThe obtained organic layer was washed with saturated brine
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure

Vorschrift

To a solution of 1-(2,6-difluorophenyl)ethanone (10.0 g) in diethyl ether (50 mL) was added anhydrous aluminum chloride (86 mg) and the mixture was stirred for 5 min. Bromine (3.3 mL) was added dropwise at 10-15° C. After stirring at room temperature for 2 hr, the mixture was poured into water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, concentrated under reduced pressure to give the title compound as a pale-yellow oil (yield 15.2 g, about 100%).

Quelle