Reaktion #1099

ord-d2942481069b43c48c9121e0d8415d47

Reaktionsgleichung

COc1c(NOCc2ccccc2)ccnc1C
4-(O-benzylhydroxylamino)-3-methoxy-2-methylpyridine
Cc1ccc(S(=O)(=O)OC2CCC3(CC2)OCCO3)cc1
8-tosyloxy-1,4-dioxaspiro[4.5]decane
→
COc1c(N(OCc2ccccc2)C2CCC3(CC2)OCCO3)ccnc1C
4-[O-Benzyl-N-(1,4-dioxaspiro[4.5]dec-8-yl)hydroxylamino]-3-methoxy-2-methylpyridine
Ausbeute 70.0%

Edukte

COc1c(NOCc2ccccc2)ccnc1C
4-(O-benzylhydroxylamino)-3-methoxy-2-methylpyridine
Cc1ccc(S(=O)(=O)OC2CCC3(CC2)OCCO3)cc1
8-tosyloxy-1,4-dioxaspiro[4.5]decane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 5 from 4-(O-benzylhydroxylamino)-3-methoxy-2-methylpyridine and 8-tosyloxy-1,4-dioxaspiro[4.5]decane. Yield: 70%

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05723450uspto-grants-1998_03