Reaktion #10989

ord-eb0f56ce48264298a0ac8f210ad7cd89

Reaktionsgleichung

CCOC(=O)C(CN1C(=O)c2c(Cl)ccc(Cl)c2C1=O)C1(C)OCCO1
ethyl 3-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate
Cc1ccc(S(=O)(=O)O)cc1.O
p-toluenesulfonic acid monohydrate
→
CCOC(=O)C(CN1C(=O)c2c(Cl)ccc(Cl)c2C1=O)C(C)=O
Ethyl 2-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate

Edukte

—
example 6 ( 20 )
CCOC(=O)C(CN1C(=O)c2c(Cl)ccc(Cl)c2C1=O)C1(C)OCCO1
ethyl 3-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate
Cc1ccc(S(=O)(=O)O)cc1.O
p-toluenesulfonic acid monohydrate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Ethyl 2-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate was prepared (264 mg, 26%) in the same manner as described in the above example 6 (20) from ethyl 3-(4,7-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (1.13 g, 2.80 mmol) and p-toluenesulfonic acid monohydrate (100 mg), and the obtained product was identified with the following NMR data.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094908B2uspto-grants-2006_08