Reaktion #1095906

Reaktionsgleichung

4,6-dichloropyrimidine

3,5-dimethylpiperidine

→

4-chloro-6-(3,5-dimethylpiperidino)pyrimidine

Ausbeute 66.0%

Reaktionsbedingungen

Vorschrift

0.3 g of 4,6-dichloropyrimidine and 0.34 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 5 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.3 g of 4-chloro-6-(3,5-dimethylpiperidino)pyrimidine. This compound had the cis/trans diastereomer originated two methyls on the pyperidine ring. The ratio of the cis/trans diastereomer was about 3.1/1.

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