Reaktion #1095644

Reaktionsgleichung

Water

Imidazole

1-bromo-4-chlorobutane

sodium hydroxide

→

1-(4-chlorobutyl)-1H-imidazole

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with chloroform
2. 2
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
3. 3
   Sonstigethe solvent was removed by distillation under the reduced pressure
4. 4
   SonstigeThe residue was purified by chromatography by development with chloroform

Vorschrift

Imidazole (680 mg), 1-bromo-4-chlorobutane (0.93 ml), tetrabutylammonium iodide (10 mg), and a 3 M aqueous sodium hydroxide solution (1 ml) were dissolved in acetone (10 ml), and the solution was stirred at 50° C. for 18 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by chromatography by development with chloroform to give an intermediate (1-(4-chlorobutyl)-1H-imidazole, 756 mg).

Quelle