Reaktion #1092995

Reaktionsgleichung

4-(2′-hydroxyethyl)piperidine

compound 96

2-chloro-4-(4-(2-methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-pyridine

3-hydroxypyrrolidine

→

solid 108

2-(4′-(4-(2-Methoxy-phenylsulfanyl)-3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-(1,2′)bipyridinyl-4-yl)-ethanol

Reaktionsbedingungen

Vorschrift

The title compound was prepared according to the procedures of Example 38E, substituting compound 76 with compound 96 (0.039 g, 0.0985 mmol) and 3-hydroxypyrrolidine with 4-(2′-hydroxyethyl)piperidine. A yellow solid 108 was obtained (0.0308 g, 64%). 1H-NMR (CDCl3, 400 MHz) δ 1.34-1.43 (m, 2H), 1.58 (q, J=6.6 Hz, 2H), 1.84-1.93 (m, 1H), 1.96-2.02 (m, 2H), 3.21-3.29 (m, 2H), 3.74 (t, J=6.2 Hz, 2H), 3.83 (s, 3H), 4.33-4.39 (m, 2H), 6.91 (d, J=6.6 Hz, 1H), 6.96 (s, 1H), 7.00-7.07 (m, 3H), 7.45-7.52 (m, 3H), 7.84 (s, 1H), 8.24 (d, J=6.6 Hz, 1H); MS (APCI) m/z 489 (M+H)+.

Quelle