Reaktion #10918

Reaktionsgleichung

cyanamide

1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine

1-(4-Isothiocyanatophenyl)-4-(1-cyclopropylmethyl)piperazine

2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone

→

{4-Amino-2-[4-(4-cyclopropylmethyl-piperazin-1-yl)-phenylamino]-thiazol-5-yl}-(3-fluoro-4-methoxy-phenyl)-methanone

Reaktionsbedingungen

Vorschrift

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-cyclopropylmethylpiperazine (of Example 14G) and 2-bromo-1-(3-fluoro-4-methoxyphenyl)ethanone (of Example 13) following the procedure used in Example 24. Mass spectrum (ES) MH+=482.

Quelle