Reaktion #1091362

Reaktionsgleichung

3-hydroxymethyl-2,5-di(4-pyridyl)-4-methylthiophene

triphenylphosphine

N,O-di-(tert-butoxycarbonyl)hydroxylamine

diethylazodicarboxylate

→

subtitle compound

Ausbeute 35.6%

N,O-Di-tert-butoxycarbonyl-[2,5-Di(4-pyridyl)-4-methylthiophen-3-yl]methylhydroxylamine

Ausbeute 35.6%

Lösungsmittel

water

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe whole was extracted with CH2Cl2 (100 mL)
2. 2
   WaschenThe organic layer was washed with brine
3. 3
   Trocknendried over MgSO4
4. 4
   Einengenconcentrated in vacuo
5. 5
   SonstigeThe residue was purified by flash chromatography
6. 6
   Wascheneluting with ethyl acetate-CH2Cl2 -MeOH (1:1:0.04)
7. 7
   SonstigeThe resulting product was purified by column chromatography on silica(NH-silica gel, FUJI SILISIA CHEMICAL LTD. DM203 5)(ethyl acetate-CH2Cl2 --MeOH=1:1:0.04)

Vorschrift

To a stirred solution of 3-hydroxymethyl-2,5-di(4-pyridyl)-4-methylthiophene (0.282 g), triphenylphosphine(0.446 g), and N,O-di-(tert-butoxycarbonyl)hydroxylamine (0.224 g), in THF (20 mL) was added diethylazodicarboxylate (0.296 g) under nitrogen. After stirring for 23 hours, the reaction mixture was poured into water (50 mL) and the whole was extracted with CH2Cl2 (100 mL). The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by flash chromatography eluting with ethyl acetate-CH2Cl2 -MeOH (1:1:0.04). The resulting product was purified by column chromatography on silica(NH-silica gel, FUJI SILISIA CHEMICAL LTD. DM203 5)(ethyl acetate-CH2Cl2 --MeOH=1:1:0.04) to give the subtitle compound (0.17 g)

Quelle