Reaktion #1091138

ord-b5af866be01a4406a64c95a12ef88dd4

Reaktionsgleichung

COC(=O)C[C@H](NC(=O)C(CSC(C)=O)Cc1ccccc1)C(=O)OC
N-(S-acetyl-2'-benzyl-3'-mercaptopropionyl)aspartic acid dimethyl ester
[Na+].[Na+].[S-2]
sodium sulphide
→
O=C(O)C[C@H](NC(=O)C(CS)Cc1ccccc1)C(=O)O
title compound
O=C(O)C[C@H](NC(=O)C(CS)Cc1ccccc1)C(=O)O
N-[2'-Benzyl-3'-mercaptopropionyl]aspartic acid

Edukte

COC(=O)C[C@H](NC(=O)C(CSC(C)=O)Cc1ccccc1)C(=O)OC
N-(S-acetyl-2'-benzyl-3'-mercaptopropionyl)aspartic acid dimethyl ester
[Na+].[Na+].[S-2]
sodium sulphide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared by Method C of Example 19

Vorschrift

Prepared by Method C of Example 19 but utilising N-(S-acetyl-2'-benzyl-3'-mercaptopropionyl)aspartic acid dimethyl ester and stirring with sodium sulphide for 3 hours. This afforded the title compound as a clear oil, an approximately equimolar mixture of diastereoisomers.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06048852uspto-grants-2000_04