Reaktion #1090485

Reaktionsgleichung

12-bromododecanol

6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide

sodium hydroxide

potassium carbonate

→

title compound

N-(12-Hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide

Lösungsmittel

chloroform

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Trocknena saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
4. 4
   SonstigeThe residue thus obtained
5. 5
   Sonstigewas chromatographed over a silica gel column

Vorschrift

To a suspension of 0.055 g of 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide, 0.011 g of tetrabutylammonium hydrogen sulfate, 0.11 g of sodium hydroxide and 0.05 g of potassium carbonate in 3 ml of toluene was added dropwise at 70° C. a solution of 12-bromododecanol in 2 ml of toluene and the mixture was stirred at 70° C. for 13 hours. The reaction solution was diluted with chloroform, washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford 0.025 g of the title compound.

Quelle