Reaktion #1090429

Reaktionsgleichung

ethyl 4-bromobutyrate

2-nitro-3-pyridinol

sodium bicarbonate

→

product ( 40 )

Ausbeute 76.0%

Ethyl 4-(2-Nitropyrid-3-yloxy)butyrate

Ausbeute 76.0%

Lösungsmittel

methanol methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwash of an ether solution of the product
2. 2
   Sonstigeto remove traces of starting phenol

Vorschrift

This compound was prepared from ethyl 4-bromobutyrate 2 and 2-nitro-3-pyridinol (39) via the procedure of Step (A), supra. Following flash chromatography (silica gel; 1.5% methanol/methylene chloride eluant) a dilute sodium bicarbonate wash of an ether solution of the product was necessary to remove traces of starting phenol. The product (40) was obtained in 76% yield as a pale yelow oil.

Quelle