Reaktion #10885

Reaktionsgleichung

3′,5′-difluoroacetophenone

bromine

→

2-bromo-1-(3,5-difluorophenyl)ethanone

Ausbeute 64.3%

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated in vacuo
2. 2
   Sonstigethe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

Vorschrift

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

Quelle