Reaktion #10871

Reaktionsgleichung

1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine

→

3-fluoro-4-(4-methyl-1-piperazinyl)benzenamine

Ausbeute 93.0%

Lösungsmittel

ethyl acetate

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered through Celite™
2. 2
   WaschenThe Celite™ was washed with ethyl acetate (50 mL)
3. 3
   Sonstigethe solvent was evaporated

Vorschrift

A solution of 1-(2-fluoro-4-nitrophenyl)-4-methylpiperazine (5.00 g, 20.9 mmol) (from Step A above) and 10% palladium-on-carbon (0.20 g, 0.2 mmol) in ethyl acetate (100 mL) and ethanol (50 mL) was hydrogenated at 50 psi in a Parr shaker for 4 h. The mixture was filtered through Celite™. The Celite™ was washed with ethyl acetate (50 mL) and the solvent was evaporated to give 3-fluoro-4-(4-methyl-1-piperazinyl)benzenamine as a white solid (4.05 g, 93%, mp 89–91° C.).

Quelle