Reaktion #10863

Reaktionsgleichung

sodium bicarbonate

2-(2,6-Dichloro-4-trifluoromethylphenylhydrazono) succinonitrile

sodium cyanide

water

→

desired title compound

Ausbeute 40.0%

2-(2,6-dichloro-4-trifluoromethylphenylhydrazino)succinonitrile

Ausbeute 40.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewhich was sealed
2. 2
   Sonstigereacted at 20° C. for 40 hours
3. 3
   Extraktionextracted (dichloromethane)
4. 4
   Waschenwashed (water)
5. 5
   Trocknendried (magnesium sulfate)
6. 6
   Sonstigeevaporated
7. 7
   Sonstigeto give a mixture which

Vorschrift

2-(2,6-Dichloro-4-trifluoromethylphenylhydrazono) succinonitrile (0.296 g, 1 mmol), sodium cyanide (0.196 g, 4 equivalents), water (1 ml) and acetic acid (5 ml) were added successively to a tube, which was sealed and reacted at 20° C. for 40 hours. The mixture was added to saturated sodium bicarbonate solution, extracted (dichloromethane), washed (water), dried (magnesium sulfate) and evaporated to give a mixture which contained 40% of the desired title compound, NMR 3.1 (m, 2H), 4.5 (m, 1H), 5.89 (m, 1H), 6.94 (d, 1H), 7.71 (s, 2H), together with 60% of unchanged starting hydrazone.

Quelle