Reaktion #10808

Reaktionsgleichung

4-acetyl-benzenesulfonamide

4-methoxy-2-(1H-tetrazol-5-ylmethoxy)-5-thiophen-2-yl-benzaldehyde

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title compound

Ausbeute 60.0%

4-{3E-[4-Methoxy-2-(1H-tetrazol-5-ylmethoxy)-5-thiophen-2-yl-phenyl]-acryloyl}-benzenesulfonamide

Ausbeute 60.0%

Reaktionsbedingungen

Vorschrift

The title compound was prepared by condensing 4-acetyl-benzenesulfonamide (Ex-26A) and 4-methoxy-2-(1H-tetrazol-5-ylmethoxy)-5-thiophen-2-yl-benzaldehyde (Ex-89A) in a similar manner as described in Ex-22. Yellow solid, mp 163–164° C. (dec), 60% yield. 1H-NMR (300 MHz, DMSO-d6) δ 8.31–8.34 (m, 3H), 7.92–8.15 (m, 4H), 7.70 (d, 1H, J=4.0 Hz), 7.54 (m, 3H), 7.15–7.17 (m, 1H), 6.92 (s, 1H), 4.64 (brs, 2H), 4.03 (s, 5H). MS (ESI) m/z=498 ([M+H]+, 100%). Anal. Calcd. for C22H19N5O5S2.1½H2O: C, 50.37; H, 4.23; N, 13.35; S, 12.23. Found: C, 50.48; H, 4.24; N, 12.95; S, 12.35.

Quelle