Reaktion #1078975

ord-5a95de4efe044e4ebb340104419cdf3a

Reaktionsgleichung

CNS(=O)(=O)c1ccc2c(c1C)CC(=O)N2
4-Methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide
O=Cc1[nH]cc2c1CCOC2=O
4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrole-1-carbaldehyde
→
CNS(=O)(=O)c1ccc2c(c1C)C(=Cc1[nH]cc3c1CCOC3=O)C(=O)N2
title compound
Ausbeute 97.0%
CNS(=O)(=O)c1ccc2c(c1C)C(=Cc1[nH]cc3c1CCOC3=O)C(=O)N2
4-Methyl-2-oxo-3-(4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrol-1-ylmethylene)-2,3-dihydro-1H-indole -5-sulfonic Acid Methylamide
Ausbeute 97.0%

Edukte

CNS(=O)(=O)c1ccc2c(c1C)CC(=O)N2
4-Methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide
O=Cc1[nH]cc2c1CCOC2=O
4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrole-1-carbaldehyde

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4-Methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide (0.2 g, 0.83 mmol) was condensed with 4-oxo-2,4,6,7-tetrahydro-pyrano[3,4-c]pyrrole-1-carbaldehyde (1.2 eq, 0.17 g) to give 0.31 g (97%) of the title compound as a yellow solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06465507B2uspto-grants-2002_10