Reaktion #1073570

Reaktionsgleichung

3-bromoacetyl-2-methylimidazo[1,2-a]pyrimidine hydrobromide

ethyl thiocarbazate

→

5-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-3,6-dihydro-1,3,4-thiadiazin-2 -one hydrobromide

Ausbeute 37.8%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 4 hours
2. 2
   TemperaturAfter cooling
3. 3
   Filtrationcrystals are collected by filtration
4. 4
   Sonstigerecrystallized from methanol twice

Vorschrift

A mixture of 5.4 g of 3-bromoacetyl-2-methylimidazo[1,2-a]pyrimidine hydrobromide, 3 g of ethyl thiocarbazate and 100 ml of acetonitrile is stirred under reflux for 4 hours. After cooling, crystals are collected by filtration and recrystallized from methanol twice to give 2 g of 5-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-3,6-dihydro-1,3,4-thiadiazin-2 -one hydrobromide as pale yellow crystals, melting at 285°-288° C. with decomposition.

Quelle