Reaktion #1073569

Reaktionsgleichung

2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide

triethylamine

chloroacetyl chloride

water

→

N'-chloroacetyl-2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide

Ausbeute 105.6%

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling
2. 2
   workup.STIRRINGAfter the mixture is stirred for 30 minutes
3. 3
   Filtrationthe precipitated crystals are collected by filtration

Vorschrift

To a mixture of 14.8 g of 2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide and 7.36 g of triethylamine in 300 ml of chloroform with stirring under cooling is added dropwise a solution of 8 g of chloroacetyl chloride in 50 ml of chloroform at 5°-10° C. After the mixture is stirred for 30 minutes, the reaction temperature is raised to room temperature and the resultant mixture is further stirred for 30 minutes. To the reaction mixture is added water and the precipitated crystals are collected by filtration to give 21 g of N'-chloroacetyl-2,6-dimethylimidazo[1,2-a]pyridine-3-carbohydrazide, melting at 290°-291° C. with decomposition.

Quelle